Vesnina next played in June at Marseille, falling at the last round of the qualifying draw she was granted a lucky loser before bowing out to No. 70 Ľubomíra Kurhajcová in straight sets despite taking the second to a close tie-break. Following this disappointing performance she reached two ITF quarterfinals in a row in Moscow losing to Maria Kondratieva and in Balashikha losing to Anastasiya Yakimova.
In late September, as a direct main-draw entrant into the ,000 tournament at Batumi, Georgia, she also reached the quarterfinals, where she lost to No. In her next events, Vesnina tried to qualify for a WTA event in the Kremlin Cup but was knocked out at the second hurdle by world No.
Petersburg an ITF event; she then qualified at Civitavecchia reaching the semifinals before losing to Maret Ani in three sets.After taking her career-first ITF title, Vesnina competed in Bucharest losing to Raluca Sandu in the second round, she stayed there to compete in Bucharest 2, where she made it through the finals losing to German Antonela Voina in a tight two sets.She then competed in Zhukovsky, Russia, as a qualifier and succeeded, then won through all the way to the semifinal of the main draw with a tight three-set quarterfinal victory over compatriot Ekaterina Bychkova en route, but was stopped in straight sets in the semifinals by Alona Bondarenko of Ukraine.She continued her good form into 2017 and won the biggest singles title of her career to date at Indian Wells, claiming her first Premier Mandatory level title.
Vesnina has been consistently one of the highest ranked doubles players during her career, ending every season since 2008 ranked within the top thirty, and every season since 2011 in the top ten; in May 2012, she entered a regular partnership with Ekaterina Makarova, becoming one of the leading teams on Tour.
61 Claudine Schaul of Luxembourg in a topsy-turvy match, and in the Bell Challenge where she succeeded for the first time in winning through qualifying into a WTA Tour main draw but lost in the first round of the main draw to Mariana Díaz Oliva. She started 2005 attempting to make headway in WTA Tour main draws and next entered the qualifying round of the Cellular South Cup but lost in straight sets to Varvara Lepchenko, the following week, she entered an ITF tournament at St.